Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity

Abstract The hepatocytes within the liver present an immense capacity to adapt to changes in nutrient availability.Here, by using high resolution volume electron microscopy, we map how hepatic subcellular spatial organization 5 Piece Casual Dining is regulated during nutritional fluctuations and as a function of liver zonation.We identify that fast

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Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial

Introduction Delirium is a major public health issue for surgical patients and their families because it is associated with increased mortality, cognitive and functional decline, prolonged hospital admission and increased healthcare expenditures.Based on preliminary data, this trial tests the hypothesis that intravenous caffeine, given postoperativ

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Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib

Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; Intermediate Kit inflammatory responses and subretinal drusen formation lead to leaky blood vessels.The current treatment method involves intravitreal injections of anti-VEGF agents, which is highly invasive and requires frequent injections administered by t

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